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There is a story about two friends, who were classmates in high school, talking about their jobs. One of them became a statistician and was working on population trends. He showed a reprint to his former classmate. The reprint started, as usual, with the Gaussian distribution and the statistician explained to his former classmate the meaning of the symbols for the actual population, for the average population, and so on. His classmate was a bit incredulous and was not quite sure whether the statistician was pulling his leg. "How can you know that?" was his query. "And what is this symbol here?" "Oh," said the statistician, "this is pi." "What is that?" "The ratio of the circumference of the circle to its diameter." "Well, now you are pushing your joke too far," said the classmate, "surely the population has nothing to do with the circumference of the circle." Naturally, we are inclined to smile about the simplicity of the classmate's approach. Nevertheless, when I heard this story, I had to admit to an eerie feeling because, surely, the reaction of the classmate betrayed only plain common sense. I was even more confused when, not many days later, someone came to me and expressed his bewilderment with the fact that we make a rather narrow selection when choosing the data on which we test our theories. "How do we know that, if we made a theory which focuses its attention on phenomena we disregard and disregards some of the phenomena now commanding our attention, that we could not build another theory which has little in common with the present one but which, nevertheless, explains just as many phenomena as the present theory?" It has to be admitted that we have no definite evidence that there is no such theory. The preceding two stories illustrate the two main points which are the subjects of the present discourse. The first point is that mathematical concepts turn up in entirely unexpected connections. Moreover, they often permit an unexpectedly close and accurate description of the phenomena in these connections. Secondly, just because of this circumstance, and because we do not understand the reasons of their usefulness, we cannot know whether a theory formulated in terms of mathematical concepts is uniquely appropriate. We are in a position similar to that of a man who was provided with a bunch of keys and who, having to open several doors in succession, always hit on the right key on the first or second trial. He became skeptical concerning the uniqueness of the coordination between keys and doors. Most of what will be said on these questions will not be new; it has probably occurred to most scientists in one form or another. My principal aim is to illuminate it from several sides. The first point is that the enormous usefulness of mathematics in the natural sciences is something bordering on the mysterious and that there is no rational explanation for it. Second, it is just this uncanny usefulness of mathematical concepts that raises the question of the uniqueness of our physical theories. In order to establish the first point, that mathematics plays an unreasonably important role in physics, it will be useful to say a few words on the question, "What is mathematics?", then, "What is physics?", then, how mathematics enters physical theories, and last, why the success of mathematics in its role in physics appears so baffling. Much less will be said on the second point: the uniqueness of the theories of physics. A proper answer to this question would require elaborate experimental and theoretical work which has not been undertaken to date. Somebody once said that philosophy is the misuse of a terminology which was invented just for this purpose. In the same vein, I would say that mathematics is the science of skillful operations with concepts and rules invented just for this purpose. The principal emphasis is on the invention of concepts. Mathematics would soon run out of interesting theorems if these had to be formulated in terms of the concepts which already appear in the axioms. Furthermore, whereas it is unquestionably true that the concepts of elementary mathematics and particularly elementary geometry were formulated to describe entities which are directly suggested by the actual world, the same does not seem to be true of the more advanced concepts, in particular the concepts which play such an important role in physics. Thus, the rules for operations with pairs of numbers are obviously designed to give the same results as the operations with fractions which we first learned without reference to "pairs of numbers." The rules for the operations with sequences, that is, with irrational numbers, still belong to the category of rules which were determined so as to reproduce rules for the operations with quantities which were already known to us. Most more advanced mathematical concepts, such as complex numbers, algebras, linear operators, Borel sets√£and this list could be continued almost indefinitely√£were so devised that they are apt subjects on which the mathematician can demonstrate his ingenuity and sense of formal beauty. In fact, the definition of these concepts, with a realization that interesting and ingenious considerations could be applied to them, is the first demonstration of the ingeniousness of the mathematician who defines them. The depth of thought which goes into the formulation of the mathematical concepts is later justified by the skill with which these concepts are used. The great mathematician fully, almost ruthlessly, exploits the domain of permissible reasoning and skirts the impermissible. That his recklessness does not lead him into a morass of contradictions is a miracle in itself: certainly it is hard to believe that our reasoning power was brought, by Darwin's process of natural selection, to the perfection which it seems to possess. However, this is not our present subject. The principal point which will have to be recalled later is that the mathematician could formulate only a handful of interesting theorems without defining concepts beyond those contained in the axioms and that the concepts outside those contained in the axioms are defined with a view of permitting ingenious logical operations which appeal to our aesthetic sense both as operations and also in their results of great generality and simplicity. The complex numbers provide a particularly striking example for the foregoing. Certainly, nothing in our experience suggests the introduction of these quantities. Indeed, if a mathematician is asked to justify his interest in complex numbers, he will point, with some indignation, to the many beautiful theorems in the theory of equations, of power series, and of analytic functions in general, which owe their origin to the introduction of complex numbers. The mathematician is not willing to give up his interest in these most beautiful accomplishments of his genius.